Journal
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
Volume 9, Issue -, Pages -Publisher
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fnbeh.2015.00130
Keywords
DNA methylation; prenatal origins; glucocorticoid receptor gene; self-regulation; infancy
Categories
Funding
- National Institute of Mental Health [R01MH094609]
- Career Development Award from the National Institute on Drug Abuse [K08DA03895902]
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We examined whether placental DNA methylation of the glucocorticoid receptor gene, NR3C1 was associated with self-regulation and neuroendocrine responses to a social stressor in infancy. Placenta samples were obtained at birth and mothers and their infants (n = 128) participated in the still face paradigm when infants were 5 months old. Infant self-regulation following the still-face episode was coded and pre-stress cortisol and cortisol reactivity was assessed in response to the still-face paradigm. A factor analysis of NR3C1 CpG sites revealed two factors: one for CpG sites 1-4 and the other for sites 5-13. DNA methylation of the factor comprising NR3C1 CpG sites 5-13 was related to greater cortisol reactivity and infant self-regulation, but cortisol reactivity was not associated with infant self-regulation. The results reveal that prenatal epigenetic processes may explain part of the development of infant self regulation
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