Journal
SURVEY OF OPHTHALMOLOGY
Volume 57, Issue 6, Pages 498-509Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.survophthal.2012.01.011
Keywords
age-related macular degeneration; vitreomacular adhesion; vitreomactilar traction; vitreous
Categories
Funding
- Novartis
- Oraya
- NeoVista
- Thrombogenics
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We explore the hypothesis that vitreomacular adhesion (VMA) and vitreomacular traction (VMT) play a role in the pathogenesis and clinical course of neovascular (wet) age-related macular degeneration (AMD). Several biological theories are offered to explain this possible association, including direct tractional force, altered vitreous oxygenation, altered diffusion coefficients of intravitreal molecules, and alterations in the pharmacokinetics of intravitreal drugs. Release of VMT may improve the clinical course of neovascular AMD, and a few case series suggest that vitrectomy can lead to both a functional and anatomic improvement. A large, randomized, controlled clinical trial is underway, investigating pharmacologic release of VMA in eyes with neovascular AMD. (Surv Ophthalmol 57:498-509, 2012. (c) 2012 Elsevier Inc. All rights reserved.)
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