Nonsteroidal Anti-inflammatory Drugs in Ophthalmology

Nonsteroidal anti-inflammatory drugs (NSAIDs) arc increasingly employed in ophthalmology to reduce miosis and inflammation, manage scleritis, and prevent and treat cystoid macular edema associated with cataract surgery. In addition, the), may decrease postoperative pain and photophobia associated with refractive surgery and may reduce the itching associated with allergic conjunctivitis. In recent years, the U.S. Food and Drug Administration has approved new topical NSAIDs, and previously approved NSAIDs have been reformulated. These additions and changes result ill different pharmacokinetics and closing intervals, which may offer therapeutic advantages. For example, therapeutic effects on diabetic retinopathy and age-related macular degeneration may now be achievable. We provide all updated review oil NSAIDs and a summary of their current uses in ophthalmology with attention to potential future applications. (Surv Ophthalmol 55:108-133, 2010. (C) 2010 Elsevier Inc. All rights reserved.)