Journal
SURGICAL ONCOLOGY-OXFORD
Volume 21, Issue 3, Pages 172-177Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.suronc.2011.09.001
Keywords
Tumor microenvironment; Cancer; Cancer Stroma; Metastasis; Inflammation; Angiogenesis; Tumorogenesis
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The concept of the tumor microenvironment, developed from Paget's seed and soil theory is made up of the cancer cells, the stromal tissue, and the extracellular matrix. In this mini-review, each of the components of this dynamic network will be examined. We will show that there are a multitude of complex interactions and a host of molecules involved in tumorogenesis and metastasis. We will further illustrate this notion with examples from the tumor microenvironment of breast cancer. Lastly, we conclude with thoughts about how this will influence the surgical field with examples of therapeutic agents already in use that target aspects of this microenvironment. (C) 2011 Elsevier Ltd. All rights reserved.
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