Journal
SURGICAL ONCOLOGY-OXFORD
Volume 21, Issue 2, Pages 143-145Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.suronc.2011.02.004
Keywords
Axillary lymph node dissection; Positive sentinel lymph node management; Z0011 trial
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The standard of practice in breast cancer surgery is that all patients with a positive sentinel node mandate an axillary lymph node dissection (ALND). Recently, this dogma has been challenged by a trial from ACOSOG (American College Of Surgeons Oncology Group) (Trial Z0011) which demonstrated that patients (without clinically/radiologically apparent axillary metastases) undergoing breast conserving surgery (i.e lumpectomy followed by whole breast radiotherapy) with positive sentinel nodes failed to derive any significant benefit by having an axillary lymph node dissection (ALND) [2]. The logical progression from this study is to question the validity of performing routine axillary lymph node dissections on all patients with positive sentinel lymph nodes (SLN). In addition to the Z0011 trial, there is emerging data that additional patients exist who fail to derive any benefit from axillary surgery. The aim of this article is to discuss the potential subpopulations of patients that may avoid unnecessary ALND in the modern era of breast cancer management. (C) 2011 Elsevier Ltd. All rights reserved.
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