Journal
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
Volume 9, Issue 11, Pages 1407-1419Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/17474124.2015.1092383
Keywords
genetics; islet cell tumor; mutation; pancreatic neuroendocrine tumor; PanNET; sequencing
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Funding
- National Institute of Health (NIH) [CA62924]
- Italian Foundation for the Research on Pancreatic Diseases (FIMP)
- Myriad Genetics
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Pancreatic neuroendocrine tumors (PanNETs) are a common and deadly neoplasm of the pancreas. Although the importance of genetic alterations in PanNETs has been known for many years, recent comprehensive sequencing studies have greatly expanded our knowledge of neuroendocrine tumorigenesis in the pancreas. These studies have identified specific cellular processes that are altered in PanNETs, highlighted alterations with prognostic implications, and pointed to pathways for targeted therapies. In this review, we will discuss the genetic alterations that play a key role in PanNET tumorigenesis, with a specific focus on those alterations with the potential to change the way patients with these neoplasms are diagnosed and treated.
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