Journal
SURGERY TODAY
Volume 42, Issue 2, Pages 181-184Publisher
SPRINGER
DOI: 10.1007/s00595-011-0106-4
Keywords
Cell; DCM; Tissue engineering; LVAD
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Funding
- Grants-in-Aid for Scientific Research [22390266] Funding Source: KAKEN
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Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by progressive heart failure, and is a leading cause of mortality and morbidity. Recently, cellular therapy for end-stage heart failure has been emerging. We herein report a 56-year-old male who received a transplant of autologous myoblast sheets manufactured in temperature-responsive culture dishes. His clinical condition improved markedly, leaving him without any arrhythmia and able to discontinue using a left ventricular assist system and avoid cardiac transplantation. These findings suggest that cellular therapy using myoblast sheets is a promising new strategy for treating patients with end-stage DCM. This method might be an effective alternative to heart transplantation in the near future.
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