Journal
SURGERY TODAY
Volume 39, Issue 2, Pages 133-136Publisher
SPRINGER
DOI: 10.1007/s00595-008-3803-x
Keywords
Cell transplantation; Heart failure; Left ventricular assist device
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Myocardial regeneration therapy shows great promise as a treatment for heart failure. We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a treatment for human ischemic cardiomyopathy. We report the results of our first clinical trial of this technique, used to treat a patient with severe heart failure caused by ischemic cardiomyopathy who was being managed with a left ventricular assist system (LVAS). After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis.
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