Journal
SURGERY
Volume 153, Issue 6, Pages 794-800Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.surg.2012.11.024
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Funding
- Ministry of Health and Welfare of Japan
- National Cancer Center Research and Development Fund
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Background. Major hepatopancreaticoduodenectomy (HPD) is an extensive surgical procedure offering the highest curability for patients with advaned biliary cancer. However, surgical morbidity associated with major HPD is high, and optimal indications for this procedure remain unclear. Methods. Between 1989 and 2010, 14 patients with widespread bile duct cancer and 5 with gallbladder cancer having biliary infiltration underwent major HPD at our hospital. Preoperative portal vein embolization was performed in 17 patients undergoing right HPD. Clinicopathologic factors and survivals following HPD were compared between patients with bile duct cancer and those with gallbladder cancer. Results. One patient who underwent right HPD for gallbladder cancer died of hepatic failure (5.3%) and 18 of the 19 patients (95%) developed postbperative pancreatic fistulas. The median hospital stay was 47 days. Depth of invasion was T3 in 1 patient and T4 in 2 patients with bile duct cancer and was T4 in all 5 patients with gallbladder cancer (P=.002). The clinical stage was IV in 3 patients (21%) with bile duct cancer and in all 5 patients with gallbladder cancer (P=.002). The 5-year survival rates and median survival rates of patients with bile duct cancer and gallbladder cancer were 45 % vs 0 and 3.3 years vs 8 months, respectively (P<.001). Conclusion. HPD can be an acceptable treatment option for widespread bile.duct cancer. However the indication for HPD in advanced-stage gallbladder cancer should be considered carefully, considering the high morbidity rate and the advanced stage of the disease.
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