Journal
SURFACE AND INTERFACE ANALYSIS
Volume 45, Issue 1, Pages 181-184Publisher
WILEY-BLACKWELL
DOI: 10.1002/sia.4910
Keywords
thermo-responsive; stimuli; switchable; ToF-SIMS; water contact angle; polymer microarray
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Funding
- Wellcome Trust [085245/Z/08/Z]
- Wellcome Trust [085245/Z/08/Z] Funding Source: Wellcome Trust
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Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discovery of new materials suitable to the specific requirements of certain biological systems. A high throughput methodology has been developed to screen a library of polymers for thermo-responsiveness, which has resulted in the identification of novel switchable materials. To elucidate the mechanism by which the materials switch, time-of-flight secondary ion mass spectrometry has been employed to analyse the top 2 nm of the polymer samples at different temperatures. The surface enrichment of certain molecular fragments has been identified by time-of-flight secondary ion mass spectrometry analysis at different temperatures, suggesting an altered molecular conformation. In one example, a switch between an extended and collapsed conformation is inferred. Copyright (C) 2012 John Wiley & Sons, Ltd.
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