Journal
SUPRAMOLECULAR CHEMISTRY
Volume 21, Issue 3-4, Pages 296-300Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10610270802438853
Keywords
manganese(II); colorimetric; sensor; displacement assay; ratiometric
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Funding
- NSF [CTS-0608889]
- NIGMS [GM-076202]
- NYU Cancer Centre and Cancer Innovations, Inc.
- National Centre for Research Resources [C06 RR-16572-01]
- National Institutes of Health
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A visible colour displacement system has been developed for the colorimetric and ratiometric detection of Mn(II) ions. The supramolecular displacement system is composed of 2-(5-bromo-2-pyridylazo)-5-[N-propyl-N-(3-sulfopropyl)amino]phenol (5-Br-PAPS), which binds Zn2+ with a change in colour and binds Mn2+ without changing colour, ethylene glycol-bis(2-aminoethylether)-N, N, N', N'-tetraacetic acid (EGTA) and Zn2+ at neutral pH. The sensing system exhibits the colour of 5-Br-PAPS itself since EGTA binds Zn2+ more strongly than 5-Br-PAPS does. However, upon presentation of Mn2+, Zn2+ is displaced from EGTA to bind 5-Br-PAPS to produce a pronounced colour change from yellow to purple. The absorbance decreases at 449nm and increases at 552nm, both linearly to Mn2+ concentration at low micromolar levels. This should be very advantageous since no suitable colorimetric reagent is available for the direct declination of Mn2+ at physiological pH.
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