Journal
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
Volume 14, Issue -, Pages 32-37Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2015.06.001
Keywords
Attention deficit/hyperactivity disorder (ADHD); Anterior cingulate cortex; Gender; MRI; Emotion regulation
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Funding
- Belgian National Fund for Scientific Research (FNRS) [3.4.516.08.F]
- Swiss National Science Foundation (SNSF) [PA00P1_139586]
- Swiss National Science Foundation (SNF) [PA00P1_139586] Funding Source: Swiss National Science Foundation (SNF)
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Female participants have been underrepresented in previous structural magnetic resonance imaging reports on attention-deficit/hyperactivity disorder (ADHD). In this study, we used optimized voxel-based morphometry to examine grey matter volumes in a sample of 33 never-medicated children with combined-type ADHD and 27 typically developing (TD) children. We found a gender-by-diagnosis interaction effect in the ventral anterior cingulate cortex (ACC), whereby boys with ADHD exhibited reduced volumes compared with TD boys, while girls with ADHD showed increased volumes when compared with TD girls. Considering the key role played by the ventral ACC in emotional regulation, we discuss the potential contribution of these alterations to gender-specific symptoms' profiles in ADHD. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org.licenses/by-nc-nd/4.0/).
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