Journal
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
Volume 14, Issue -, Pages 50-61Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2015.06.003
Keywords
Diffusion tensor imaging; White matter; Orbitofrontal cortex; Autism; Conduct disorder; Anti social personality disorder
Categories
Funding
- National Institute of Health [RO1 MH091113]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH091113] Funding Source: NIH RePORTER
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The uncinate fasciculus (UF) is a long-range white matter tract that connects limbic regions in the temporal lobe to the frontal lobe. The UF is one of the latest developing tracts, and continues maturing into the third decade of life. As such, individual differences in the maturational profile of the UF may serve to explain differences in behavior. Indeed, atypical macrostructure and microstructure of the UF have been reported in numerous studies of individuals with developmental and psychiatric disorders such as social deprivation and maltreatment, autism spectrum disorders, conduct disorder, risk taking, and substance abuse. The present review evaluates what we currently know about the UF's developmental trajectory and reviews the literature relating UF abnormalities to specific disorders. Additionally, we take a dimensional approach and critically examine symptoms and behavioral impairments that have been demonstrated to cluster with UF aberrations, in an effort to relate these impairments to our speculations regarding the functionality of the UF. We suggest that developmental disorders with core problems relating to memory retrieval, reward and valuation computation, and impulsive decision making may be linked to aberrations in uncinate microstructure. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/).
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