Journal
SUPPORTIVE CARE IN CANCER
Volume 20, Issue 9, Pages 2073-2081Publisher
SPRINGER
DOI: 10.1007/s00520-011-1316-4
Keywords
Swallowing; Nutrition; Oropharyngeal cancer; Chemoradiation; Altered fractionation radiotherapy
Funding
- Queensland Cancer Council
- Cancer Collaborative Group, Princess Alexandra Hospital
- Radiation Oncology Department, Princess Alexandra Hospital
- Speech Pathology Australia
- Allied Health Research Scheme, Princess Alexandra Hospital
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Altered fractionation radiotherapy with concomitant boost (AFRT-CB) may be considered an alternative treatment for patients not appropriate for chemoradiation (CRT). As functional outcomes following AFRT-CB have been minimally reported, this exploratory paper describes the outcomes of patients managed with AFRT-CB or CRT at 6 months post-treatment. Using a cross-sectional analysis design, functional outcomes of 14 AFRT-CB and 17 CRT patients with T1-T3 oropharyngeal cancers were explored at 6 months post-treatment. Clinical and instrumental swallow assessments, weight and nutritional status, and the functional impact of treatment were examined. Inferior outcomes were observed for the CRT patients on the RBHOMS (p = 0.03) which was reflected in diet and fluid restrictions with 18% of the CRT group requiring modified fluids and diets. Although a trend (p = 0.07) was noted for increased lingual deficits and aspiration risk for fluids in the CRT group, no other significant differences were observed. Both groups experienced an average of 10 kg weight loss and reported reduced general and swallowing-related function. These preliminary data suggest functional outcomes following AFRT-CB and CRT were largely comparable at 6 months post-treatment. Treatment intensification in any form may contribute to impaired function which requires multidimensional intervention. Larger cohort investigations with systematic methodology are needed to further examine these initial findings.
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