Journal
CURRENT STEM CELL RESEARCH & THERAPY
Volume 10, Issue 4, Pages 329-338Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X10666150305105114
Keywords
Annulus fibrosus; endogenous repair; intervertebral disc; nucleus pulposus; progenitor cells; stem cell niche
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Funding
- AOSpine International through AOSpine Research Network (AOSRN) [104979]
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Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential of endogenous repair in the IVD, the recent findings on endogenous IVD progenitor cells, and stem cell niches involved in IVD endogenous repair. We also highlight the factors which may restrict IVD self-healing. Ultimately, advanced therapeutic attempts to boost endogenous repair in the IVD are discussed, including bioactive factor delivery, gene therapy, activation of endogenous IVD progenitor cells and chemokine mediated stem cell homing.
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