Journal
CURRENT OPINION IN VIROLOGY
Volume 15, Issue -, Pages 119-126Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2015.10.001
Keywords
-
Categories
Funding
- NIH [AI34014, AI48740, AI46435]
- Grand Challenges in Global Health through the Foundation for NIH
Ask authors/readers for more resources
Arthropod-borne (arbo) viruses infect hematophagous arthropods (vectors) to maintain virus transmission between vertebrate hosts. The mosquito vector actively controls arbovirus infection to minimize its fitness costs. The RNA interference (RNAi) pathway is the major antiviral response vectors use to restrict arbovirus infections. We know this because depleting RNAi gene products profoundly impacts arbovirus replication, the antiviral RNAi pathway genes undergo positive, diversifying selection and arboviruses have evolved strategies to evade the vector's RNAi responses. The vector's RNAi defense and arbovirus countermeasures lead to an arms race that prevents potential virus-induced fitness costs yet maintains arbovirus infections needed for transmission. This review will discuss the latest findings in RNAi-arbovirus interactions in the model insect (Drosophila melanogaster) and in specific mosquito vectors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available