Journal
CURRENT OPINION IN VIROLOGY
Volume 14, Issue -, Pages 138-144Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2015.09.007
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Funding
- National Institutes Health [P01CA174439, R01177423, R01171979, P30DK050306, P30CA016520, U54CA190158]
- Avon foundation for women
- Deutsche Krebshilfe
- Deutsche Jose Carreras Leukamie-Stiftung [10-1963-Ke-1, DJCLS R 07/11]
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EBV drives resting B cells to continuous proliferating latently infected cells. A restricted program of viral transcription contributes to latency and cell proliferation important for growth transformation. Recent interest in latency and transformation has provided new data about the roles of the EBV encoded latent proteins and non-coding RNAs. We broadly describe the transcription, epigenetic, signaling and super-enhancer functions of the latent nuclear antigens in regulating cellular transcription; the role of LMP2 in utilization of the autophagosome to control cell death, and the association between LMP1, the linear ubiquitin chain assembly complex and TRAF1 which are important for transformation. This review explores recent discoveries with new insights into therapeutic avenues for EBV related malignancies.
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