Journal
CURRENT HEMATOLOGIC MALIGNANCY REPORTS
Volume 10, Issue 2, Pages 96-103Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11899-015-0253-6
Keywords
Bone marrow microenvironment; Acute myeloid leukemia (AML); Leukemia stem cell (LSC); Hematopoietic stem cell (HSC); Endosteal niche; Vascular niche
Categories
Funding
- NIH/NCI [R01 CA155056-04, P30 CA016672]
- Leukemia and Lymphoma Society
Ask authors/readers for more resources
As part of the dynamic interactions between leukemic cells and cells of the bone marrow microenvironment, specific niches provide a sanctuary where subpopulations of leukemic cells evade chemotherapy-induced death and acquire a drug-resistant phenotype. This review focuses on the cellular and molecular biology of the leukemia stem cell (LSC) niche and of microenvironment/leukemia interactions. Key emerging therapeutic targets include chemokine receptors, adhesion molecules, the sympathetic nervous system, and hypoxia-related proteins, as well as the genetic and epigenetic abnormalities of the leukemia-associated stroma. The complex interplay between LSCs and microenvironment components provides a rationale for appropriately tailored molecular therapies designed to improve outcomes in leukemia. Further understanding of the contribution of the bone marrow niche to the process of leukemogenesis may provide new targets that allow destruction of LSCs without adversely affecting normal stem cell self-renewal.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available