Journal
CHEMPLUSCHEM
Volume 80, Issue 7, Pages 1104-1112Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201402398
Keywords
biomaterials; biosilica; diatoms; drug delivery; TEMPO
Categories
Funding
- MIUR [PON 02_00563_3316357, 2011 F81J12000380001, PONa3_00369]
- Universita degli Studi di Bari Aldo Moro
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Nanostructured biosilica produced by Thalassiosira weissflogii diatoms is covalently functionalized with the cyclic nitroxide 2,6,6-tetramethylpiperidine-N-oxyl (TEMPO), an efficient scavenger of reactive oxygen species (ROS) in biological systems. Drug delivery properties of the TEMPO-functionalized biosilica are studied for Ciprofloxacin, an antimicrobial thoroughly employed in orthopedic or dental implant related infections. The resulting TEMPO-biosilica, combining Ciprofloxacin drug delivery with anti-oxidant properties, is demonstrated to be a suitable material for fibroblasts and osteoblast-like cells growth.
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