Journal
STRUCTURE
Volume 19, Issue 7, Pages 1011-1020Publisher
CELL PRESS
DOI: 10.1016/j.str.2011.03.023
Keywords
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Funding
- UK MRC
- European Commission [031220FP6]
- MRC [G1000099, G19/3] Funding Source: UKRI
- Medical Research Council [G1100525, G19/3, G1000099] Funding Source: researchfish
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The morphogenesis of poxviruses such as vaccinia virus (VACV) sees the virion shape mature from spherical to brick-shaped. Trimeric capsomers of the VACV D13 protein form a transitory, stabilizing lattice on the surface of the initial spherical immature virus particle. The crystal structure of D13 reveals that this major scaffolding protein comprises a double 13 barrel jelly-roll subunit arranged as pseudo-hexagonal trimers. These structural features are characteristic of the major capsid proteins of a lineage of large icosahedral double-stranded DNA viruses including human adenovirus and the bacteriophages PRD1 and PM2. Structure-based phylogenetic analysis confirms that VACV belongs to this lineage, suggesting that (analogously to higher organism embryogenesis) early poxvirus morphogenesis reflects their evolution from a lineage of viruses sharing a common icosahedral ancestor.
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