Journal
STRUCTURE
Volume 17, Issue 1, Pages 8-14Publisher
CELL PRESS
DOI: 10.1016/j.str.2008.12.003
Keywords
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Funding
- NIH [P50 GM073197]
- Protein Structure Initiative [U54 GM074961]
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G-protein-coupled receptors (GPCRs) are the largest family of proteins in the human genome. Within the last year, we have witnessed a relative explosion in the amount of structural information available for the GPCR family with two new structures of opsin in the presence and absence of transducin peptide, four new structures of beta-adrenergic receptors, and a recent structure of the human adenosine A(2A) receptor. The new biological insight being gained, such as the highly divergent extracellular loops and areas of structural convergence within the transmembrane helices, allows us to chart a course for further investigation into this important class of membrane proteins.
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