Journal
CELL REPORTS
Volume 11, Issue 2, Pages 261-269Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.03.017
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Funding
- Core Research for Evolutional Science and Technology (CREST) program of the Japan Science and Technology Agency (JST)
- JSPS KAKENHI [23220009, 24650164]
- MEXT [25115002]
- Mitsubishi Foundation
- Uehara Memorial Foundation
- Takeda Science Foundation
- Hokugin Research Grant
- Grants-in-Aid for Scientific Research [26640008, 23220009, 25293136, 24650164, 25115002, 26115523, 25430015] Funding Source: KAKEN
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Memory is thought to be stored in the brain as an ensemble of cells activated during learning. Although optical stimulation of a cell ensemble triggers the retrieval of the corresponding memory, it is unclear how the association of information occurs at the cell ensemble level. Using optogenetic stimulation without any sensory input in mice, we found that an artificial association between stored, non-related contextual, and fear information was generated through the synchronous activation of distinct cell ensembles corresponding to the stored information. This artificial association shared characteristics with physiologically associated memories, such as N-methyl-D-aspartate receptor activity and protein synthesis dependence. These findings suggest that the association of information is achieved through the synchronous activity of distinct cell ensembles. This mechanism may underlie memory updating by incorporating novel information into pre-existing networks to form qualitatively new memories.
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