Journal
CELL REPORTS
Volume 12, Issue 7, Pages 1196-1204Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.07.026
Keywords
-
Categories
Funding
- NIH-Office of Research Infrastructure Programs [P40 OD010440]
- NIH [R37AG024365, R01AG042679, R01ES021667, T32AG000266, R01AG025549, R01AG043080]
- NIH/NIA [1K99AG042495]
- George E. Hewitt Foundation for Medical Research
- Salk Center for Nutritional Genomics from the Leona M. & Harry B. Helmsley Charitable Trust
- Glenn Foundation for Medical Research
Ask authors/readers for more resources
Integrating stress responses across tissues is essential for the survival of multicellular organisms. The metazoan nervous system can sense protein-misfolding stress arising in different subcellular compartments and initiate cytoprotective transcriptional responses in the periphery. Several subcellular compartments possess a homotypic signal whereby the respective compartment relies on a single signaling mechanism to convey information within the affected cell to the same stress-responsive pathway in peripheral tissues. In contrast, we find that the heat shock transcription factor, HSF-1, specifies its mode of transcellular protection via two distinct signaling pathways. Upon thermal stress, neural HSF-1 primes peripheral tissues through the thermosensory neural circuit to mount a heat shock response. Independent of this thermosensory circuit, neural HSF-1 activates the FOXO transcription factor, DAF-16, in the periphery and prolongs lifespan. Thus a single transcription factor can coordinate different stress response pathways to specify its mode of protection against changing environmental conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available