Journal
CELL REPORTS
Volume 12, Issue 2, Pages 313-325Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.06.016
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Funding
- University of Geneva
- European Research Council [ERC-2009-StG-243344-NEUROCHEMS]
- Swiss National Science Foundation (SNF) [PP0033_119169, PP00P3_139189, PP00P2_146318, 31003A_153410, CR33I13_143723, 31003A_149753, 51AU40_125759]
- National Center of Competence in Research (NCCR) SYNAPSY-The Synaptic Bases of Mental Diseases''
- Novartis Foundation for Medical Research
- Carlos & Elsie de Reuter Foundation
- Ernst & Lucie Schmidheiny Foundation
- European Molecular Biology Organization
- Swiss National Science Foundation (SNF) [31003A_149753, 31003A_153410, PP0033_119169, PP00P2_146318, PP00P3_139189] Funding Source: Swiss National Science Foundation (SNF)
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Functional brain-imaging techniques used in humans and animals, such as functional MRI and intrinsic optical signal (IOS) imaging, are thought to largely rely on neurovascular coupling and hemodynamic responses. Here, taking advantage of the well-described micro-architecture of the mouse olfactory bulb, we dissected the nature of odor-evoked IOSs. Using in vivo pharmacology in transgenic mouse lines reporting activity in different cell types, we show that parenchymal IOSs are largely independent of neurotransmitter release and neurovascular coupling. Furthermore, our results suggest that odor-evoked parenchymal IOSs originate from changes in light scattering of olfactory sensory neuron axons, mostly due to water movement following action potential propagation. Our study sheds light on a direct correlate of neuronal activity, which may be used for large-scale functional brain imaging.
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