Journal
CELL REPORTS
Volume 13, Issue 2, Pages 365-375Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.09.003
Keywords
-
Categories
Funding
- State of Geneva
- Swiss National Science Foundation [310030B_135704, 31003A_146984]
- Synapsis Foundation
- Danish Medical Research Council [09-063399, 09-066319]
- Lundbeck Foundation [R77-A6808]
- Carlsberg Foundation
- Swiss National Science Foundation (SNF) [310030B_135704, 31003A_146984] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain. In particular, astrocytes actively take up glutamate and may use it through oxidative glutamate dehydrogenase (GDH) activity. Here, we investigated the significance of glutamate as energy substrate for the brain. Upon glutamate exposure, astrocytes generated ATP in a GDH-dependent way. The observed lack of glutamate oxidation in brain-specific GDH null CnsGludl(-1-) mice resulted in a central energy-deprivation state with increased ADP/ATP ratios and phospho-AMPK in the hypothalamus. This induced changes in the autonomous nervous system balance, with increased sympathetic activity promoting hepatic glucose production and mobilization of substrates reshaping peripheral energy stores. Our data reveal the importance of glutamate as necessary energy substrate for the brain and the role of central GDH in the regulation of whole-body energy homeostasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available