Journal
STROKE
Volume 43, Issue 6, Pages 1609-+Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.111.643130
Keywords
behavioral neurology; cerebral infarct; cerebrovascular disease; neuropsychology; stroke care; transient ischemic attack
Categories
Funding
- American Stroke Association-Bugher Foundation Stroke Prevention Research Center
- Bristol-Myers Squibb/Sanofi Pharmaceuticals
- Agency for Healthcare Research and Quality [U18HS016964]
- National Institutes of Health [1D43-TW008308-01]
- Agency for Healthcare Research and Quality
- Veterans' Affair
- Foundation for Informed Medical Decision Making, Department of Defense (FIMDM)
- Bristol Myers Squibb-Sanofi
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Background and Purpose-Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. Methods-This study was a secondary analysis of a prospective cohort registry that enrolled subjects from 2006 to 2008 in the United States. Depression (defined by the Patient Health Questionnaire-8 score >= 10) and medication use were prospectively assessed 3 and 12 months after hospitalization in 1450 subjects with ischemic stroke and 397 subjects with TIA. Results-The proportional frequency of depression after stroke and TIA was similar at 3 months (17.9% versus 14.3%, P=0.09) and at 12 months (16.4% versus 12.8%, P=0.08). The rates of newly identified depression between 3 and 12 months were also similar (8.7% versus 6.2%, P=0.12). Persistent depression (defined as Patient Health Questionnaire-8 score >= 10 at both 3 and 12 months) was present in 134 (9.2%) of those with stroke and in 30 (7.6%) of those with TIA. Younger age, greater stroke-related disability, and inability to work at 3 months were associated with persistent depression in subjects with stroke. Among subjects with persistent depression, 67.9% of those with stroke and 70.0% of those with TIA were not using antidepressants at either time point (P=0.920). Conclusions-Stroke and TIA subjects had a similar frequency of depression at 3 and 12 months after hospitalization and similar rates of newly identified depression between 3 and 12 months. A high proportion of those with persistent depression was untreated. (Stroke. 2012;43:1609-1616.)
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