Journal
CELL REPORTS
Volume 13, Issue 9, Pages 1828-1841Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.10.055
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Funding
- LE&RN Postdoctoral Fellowship
- UQ Postdoctoral Fellowship
- NHMRC/NHF CDF2 [1083811]
- NHMRC CDF1 [1011242]
- Medical Research Council [U117581329]
- NHMRC Fellowship [1044041]
- NHMRC grant [1050138]
- ARC project [DP150103110]
- Cariplo Foundation
- MRC [MC_U117581329] Funding Source: UKRI
- Medical Research Council [MC_U117581329] Funding Source: researchfish
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Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood. We report the visualization of zebrafish lymphatic precursor cell dynamics during fate restriction. In the cardinal vein, cellular commitment is linked with the division of bipotential Prox1-positive precursor cells, which occurs immediately prior to sprouting angiogenesis. Following precursor division, identities are established asymmetrically in daughter cells; one daughter cell becomes lymphatic and progressively upregulates Prox1, and the other downregulates Prox1 and remains in the vein. Vegfc drives cell division and Prox1 expression in lymphatic daughter cells, coupling signaling dynamics with daughter cell fate restriction and precursor division.
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