Journal
CELL REPORTS
Volume 13, Issue 7, Pages 1432-1443Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.10.012
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)-Japan Society for the Promotion of Science (JSPS) [24111004, 23249025, 23659241, 25860361]
- Naito Foundation
- Grants-in-Aid for Scientific Research [23659241, 24111001, 25860361, 15K19130, 24111004] Funding Source: KAKEN
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Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-mapping analysis of cells that transcribe beta 5t, a cTEC trait expressed in bipotent progenitors, during a given period in mice. We show that, in adult mice, most mTECs are derived from progenitors that transcribe beta 5t during embryogenesis and the neonatal period up to 1 week of age. The contribution of adult beta 5t(+) progenitors was minor even during injury-triggered regeneration. Our results further demonstrate that adult mTEC-restricted progenitors are derived from perinatal beta 5t(+) progenitors. These results indicate that the adult thymic medullary epithelium is maintained and regenerated by mTEC-lineage cells that pass beyond the bipotent stage during early ontogeny.
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