Journal
STROKE
Volume 42, Issue 12, Pages 3352-U67Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.111.619544
Keywords
epidemiology; physical activity; stroke
Categories
Funding
- National Cancer Institute [CA-34944, CA-40360, CA-097193]
- National Heart, Lung, and Blood Institute, Bethesda, MD [HL-26490, HL-34595]
- National Institute of Aging [AG-00158]
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Background and Purpose-In studies enrolling patients with stroke, higher levels of prestroke physical activity are associated with better functional outcomes. However, prospective studies evaluating this association are sparse. Using a cohort of initially healthy men, we aimed to prospectively assess the association between physical activity and functional outcomes from cerebral vascular events. Methods-We conducted a prospective cohort study among 21 794 men enrolled in the Physician's Health Study who provided information on physical activity at baseline and who did not have a history of stroke or transient ischemic attack (TIA). Baseline levels of physical activity were categorized as: vigorous exercise <1, 1, 2 to 4, and >= 5 times/week. Possible functional outcomes included TIA and stroke with modified Rankin Scale score of 0 to 1, 2 to 3, or 5 to 6. Multinomial logistic regression was used to determine the association between physical activity and functional outcomes from cerebral vascular events. Results-After a mean of 20.2 years of follow-up, 761 TIAs, 1146 ischemic strokes, 221 hemorrhagic strokes, and 11 strokes of unknown type occurred. Compared with men who did not experience a stroke or TIA and who exercise vigorously <1 time/week, men who exercise vigorously >= 5 times/week had adjusted relative risk (95% CIs) of 0.67 (0.53-0.86) for TIA, 0.84 (0.61-1.14) for stroke with modified Rankin Scale score 0 to 1, 0.85 (0.67-1.08) for modified Rankin Scale score 2 to 3, and 1.12 (0.78-1.60) for modified Rankin Scale score 5 to 6 after total stroke. Other levels of physical activity did not have a significant impact on the risk of our outcomes. Conclusions-Physical activity before TIA or stroke does not appear to influence functional outcomes after cerebral vascular events. (Stroke. 2011;42:3352-3356.)
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