Journal
CELL REPORTS
Volume 12, Issue 11, Pages 1853-1864Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.08.016
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Funding
- ANR REGULncRNA
- French government (grant DYNAMO) [ANR-11-LABX-0011-01]
- Ministere pour la Recherche et la Technologie (MNRT)
- la Fondation pour la Recherche Medicale (FRM)
- la Fondation Edmond de Rothschild
- ERC EpincRNA starting grant
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Transcriptome analyses have revealed that convergent gene transcription can produce many 30-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 30-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 30-overlapping messengers or their impact on gene expression. Here, we demonstrate that the complementary tails of 30-overlapping mRNAs can interact in the cytoplasm and promote post-transcriptional regulatory events including no-go decay (NGD) in Saccharomyces cerevisiae. Genome-wide experiments confirm that these messenger-interacting mRNAs (mimRNAs) form RNA duplexes in wild-type cells and thus have potential roles in modulating the mRNA levels of their convergent gene pattern under different growth conditions. We show that the post-transcriptional fate of hundreds of mimRNAs is controlled by Xrn1, revealing the extent to which this conserved 50-30 cytoplasmic exoribonuclease plays an unexpected but key role in the post-transcriptional control of convergent gene expression.
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