Journal
CELL REPORTS
Volume 13, Issue 6, Pages 1103-1109Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.09.077
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Funding
- NIH [R01 MH101244]
- Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z1AES103266]
- National Institute of Environmental Health Sciences (NIH/NIEHS) [4R00ES022633-02]
- Russian Science Foundation [14-24-00155]
- Russian Science Foundation [14-24-00155] Funding Source: Russian Science Foundation
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An antiviral component of the human innate immune system-the APOBEC cytidine deaminases-was recently identified as a prominent source of mutations in cancers. Here, we investigated the distribution of APOBEC-induced mutations across the genomes of 119 breast and 24 lung cancer samples. While the rate of most mutations is known to be elevated in late-replicating regions that are characterized by reduced chromatin accessibility and low gene density, we observed a marked enrichment of APOBEC mutations in early-replicating regions. This unusual mutagenesis profile may be associated with a higher propensity to form single-strand DNA substrates for APOBEC enzymes in early-replicating regions and should be accounted for in statistical analyses of cancer genome mutation catalogs aimed at understanding the mechanisms of carcinogenesis as well as highlighting genes that are significantly mutated in cancer.
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