Journal
STROKE
Volume 41, Issue 1, Pages 181-183Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.109.567826
Keywords
neuroprotectants; poly(ADP-ribose); PARP; NAD; ATP
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Funding
- Italian PRIN 2007
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Background and Purpose-Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in ischemic preconditioning of the heart and cultured neurons, but its role in brain ischemic preconditioning is unknown. Summary of Report-We report that 5-minute bilateral common carotid artery occlusion (BCCAO) in the mouse prompted reduction of infarct volumes triggered 24 hours later by 20-minute middle cerebral artery occlusion (MCAO). Pharmacological PARP-1 inhibition between BCCAO and MCAO did not impair preconditioning. The contents of the PARP-1 substrate NAD, those of its product poly(ADP-ribose), caspase-3 activation, and PARP-1 expression did not change after BCCAO within the preconditioned tissue. PARP-1 KO mice were similarly protected by the 5-minute BCCAO. Conclusion-Data demonstrate that, at variance with the heart, PARP-1 is dispensable for brain ischemic preconditioning. (Stroke. 2010;41:181-183.)
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