Journal
STROKE
Volume 40, Issue 9, Pages 2965-2968Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.109.558346
Keywords
TRPM7; tag-single-nucleotide polymorphisms; ischemic stroke; risk factors
Categories
Funding
- National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) [CA-34944, CA-40360, HL-26490, HL-34595]
- National Institute of Environmental Health Sciences/NIH [ES-14462]
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Background and Purpose-Transient receptor potential cation channel, subfamily M, member 7 (TRPM7), has been implicated in ischemic brain damage, a major source of morbidity and mortality in westernized society. We hypothesized that TRPM7 gene variation might play a role in the risk of ischemic stroke. Methods-From a group of DNA samples collected at baseline in a prospective cohort of 14 916 initially healthy American men, we assessed 16 TRPM7 tag-single-nucleotide polymorphisms (SNPs) (dbSNP: rs11854949, rs4775899, rs11635825, rs12905120, rs16973487, rs7173321, rs7163283, rs17520378, rs17520350, rs4775892, rs7174839, rs17645523, rs3109894, rs616256, rs11070795, and rs313158) from 245 white men who subsequently had an incident ischemic stroke and from 245 age-and smoking habit-matched white men who remained free of reported vascular disease during follow-up (controls). Results-All SNPs examined were in Hardy-Weinberg equilibrium. Overall allele, genotype, and haplotype distributions were similar between cases and controls. Marker-by-marker conditional logistic-regression analysis, adjusted for potential risk factors, showed no evidence for an association between any of the SNPs tested and ischemic stroke. Further investigation with an Entropy Blocker-defined, haplotype-based approach showed similar null findings. Prespecified analysis limited to participants without baseline diabetes and hypertension (ie, low-risk group) again showed similar null findings. Conclusions-The present prospective investigation provides no evidence of a role for the TRPM7 gene in the risk of incident ischemic stroke. (Stroke. 2009;40:2965-2968.)
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