Journal
STROKE
Volume 39, Issue 9, Pages 2439-2443Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.107.510073
Keywords
stroke; women; smoking
Categories
Funding
- Office of Research and Development
- Medical Research Service
- Research Enhancement Award Program in Stroke
- Geriatrics Research, Education, and Clinical Center
- Baltimore VAMC Center for Excellence in Robotics
- Department of Veterans Affairs
- American Heart Association [0665352U]
- Cardiovascular Health Branch
- Division of Adult and Community Health,
- Centers for Disease Control
- National Institute of Neurological Disorders and Stroke (NINDS)
- NIH Office of Research on Women's Health (ORWH) [R01 NS45012]
- National Institute on Aging (NIA) Pepper Center [P60 12583]
- University of Maryland General Clinical Research Center
- General Clinical Research Centers Program
- National Center for Research Resources (NCRR)
- NIH [M01 RR 165001]
- University of Maryland
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Background and Purpose-Although cigarette smoking is known to be a risk factor for ischemic stroke, there are few data on the dose-response relationship between smoking and stroke risk in a young ethnically diverse population. Methods-We used data from the Stroke Prevention in Young Women Study, a population-based case-control study of risk factors for ischemic stroke in women aged 15 to 49 years to examine the relationship between cigarette smoking and ischemic stroke. Historical data, including smoking history, was obtained through standardized interviews. Odds ratios (OR) were estimated using logistic regression. Cases (n = 466) were women with stroke in the greater Baltimore-Washington area, and controls (n = 604) were women free of a stroke history identified by random digit dialing. Results-After multivariable adjustment, the OR comparing current smokers to never smokers was 2.6 (P < 0.0001); no difference in stroke risk was observed between former smokers and never smokers. Adjusted OR increased with increasing number of cigarettes smoked per day (OR 2.2 for 1 to 10 cigs/d; 2.5 for 11 to 20 cigs/d; 4.3 for 21 to 39 cigs/d; 9.1 for 40 or more cigs/d). Conclusion-These results suggest a strong dose-response relationship between cigarette smoking and ischemic stroke risk in young women and reinforce the need for aggressive smoking cessation efforts in young adults.
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