Journal
STROKE
Volume 40, Issue 3, Pages S24-S27Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.108.526814
Keywords
brain infarction; brain ischemia; cerebral infarct; CT; magnetic resonance; neuroradiology; reprefusion; tPA
Categories
Funding
- National Center for Research Resources [KL2 RR024130]
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Revascularization therapies for acute stroke patients aim to rescue the ischemic penumbra by restoring the patency of the occluded artery (recanalization) and the downstream capillary blood flow (reperfusion). This article reviews the definition of recanalization and reperfusion used in stroke clinical trials and their limitations and proposes a study design to determine the relative importance of recanalization, reperfusion, and collateral flow in evaluating the efficacy of revascularization therapies for acute ischemic stroke. (Stroke. 2009;40[suppl 1]:S24-S27.)
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