Journal
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
Volume 14, Issue 4, Pages 368-375Publisher
INFORMA HEALTHCARE
DOI: 10.3109/10253890.2010.544345
Keywords
Corticosterone; hypothalamic paraventricular nucleus; hypothalamic-pituitary-adrenal axis; medial amygdala; PACAP; stress
Funding
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [21390069, 23790295] Funding Source: KAKEN
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Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide widely distributed in the nervous system. Recently, PACAP was shown to be involved in restraint stress-induced corticosterone release and concomitant expression of the genes involved in hypothalamic--pituitary--adrenal (HPA) axis activation. Therefore, in this study, we have addressed the types of stressors and the levels of the HPA axis in which PACAP signaling is involved using mice lacking PACAP (PACAP
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