Journal
STEROIDS
Volume 78, Issue 12-13, Pages 1263-1272Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2013.09.006
Keywords
Cholest-5-en-7-one; Pyrazolines; Anticancer; MTT; SEM
Funding
- UGC, New Delhi India [Acad/D-742/MR]
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The synthesis and anti-tumor activity screening of new steroidal derivatives (4-18) containing pharmacologically attractive pyrazoline moieties are performed. During in vitro anticancer evaluation, the newly synthesized compounds displayed moderate to good cytotoxicity on cervical and leukemia cancer cell lines. In addition these compounds were found to be nontoxic to normal cell (PBMCs) (IC50 > 50 mu M). The structure-activity relationship is also discussed. The most effective anticancer compound 9 was found to be active with IC50 value of 10.6 mu M. It demonstrated significant antiproliferative influence on Jurkat cell lines. The morphological changes and growth characteristics of HeLa cells treated with compound 4 were analyzed by means of SEM. (C) 2013 Elsevier Inc. All rights reserved.
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