Journal
STEROIDS
Volume 77, Issue 13, Pages 1352-1358Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2012.08.005
Keywords
Asymmetric dimethylarginine; Apelin; Tumor necrosis factor-alpha; Hyperandrogenism; Cardiovascular disease; Polycystic ovary syndrome
Funding
- National Research Foundaion of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0003065]
- National Research Foundation of Korea [2010-0003065] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Polycystic ovary syndrome (PCOS) is associated with multiple risk factors for cardiovascular disease (CVD), including insulin resistance, type 2 diabetes mellitus, obesity, hypertension, and dyslipidemia. In addition, hyperandrogenism may contribute to the pathogenesis of CVD, independent of obesity and insulin resistance. We investigated serum levels of asymmetric dimethylarginine (ADMA), apelin, and tumor necrosis factor (TNF)-alpha as CVD risk markers and their relationship with hyperandrogenism in non-obese women with PCOS. In this study were included 82 non-obese women with PCOS and 33 controls. Women with PCOS were further divided into two groups: women with hyperandrogenism (HA-PCOS, n = 37) and those without hyperandrogenism (NA-PCOS, n = 45). Serum ADMA, apelin, and TNF-alpha levels were compared among the three groups and their relationship with hyperandrogenism was evaluated. Serum ADMA levels were significantly higher in the HA-PCOS group than in the NA-PCOS and control groups (0.45 +/- 0.09 vs. 0.38 +/- 0.08 vs. 0.40 +/- 0.07; P < 0.0005). Serum TNF-alpha levels were significantly higher among women with PCOS compared with controls (2.91 +/- 1.25 vs. 1.74 +/- 0.77; P < 0.001) and in the HA-PCOS group compared with the NA-PCOS group (3.21 +/- 1.24 vs. 2.60 +/- 1.24; P < 0.0001). Both PCOS groups had significantly lower serum apelin levels compared with controls (1.31 +/- 0.54 vs. 1.16 +/- 0.34 vs. 2.78 +/- 1.10; P < 0.0001). ADMA and TNF-alpha were positively correlated with total testosterone (r = 0.219, P = 0.022; r = 0.332, P < 0.001, respectively) and free androgen index (r = 0.287, P = 0.002; r = 0.289, P = 0.002, respectively), whereas apelin was negatively correlated with these parameters (r = 0.362, P < 0.001; r = 0.251, P = 0.008). These findings may indicate that non-obese women with PCOS are at an increased risk for CVD, which is further aggravated by hyperandrogenism. (C) 2012 Elsevier Inc. All rights reserved.
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