Journal
STEROIDS
Volume 77, Issue 6, Pages 710-715Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2012.03.002
Keywords
Heterosteroids; Steroidal[17,16-d]triazolopyrimidines; 1,2,4-Triazolo[1,5-a]pyrimidines; Anticancer activity
Funding
- National Natural Sciences Foundation of China [81172937]
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The preparation of steroidal[17,16-d][1,2,4]triazolo[1,5-a]pyrimidines and their biological evaluation as potential anticancer agents are herein reported. These novel heterosteroids (2, 4) were prepared through the condensation reaction of 3-amino-1,2,4-triazole with 16-arylidene-17-ketosteroids (1, 3). All the synthesized compounds were evaluated for their anticancer activity in vitro against PC-3 (human prostatic carcinoma), MCF-7 (human breast carcinoma) and EC9706 (human esophageal carcinoma) cell lines. Among the screened compounds, 2i, 2n and 4f showed significant inhibitory activity against all the three human cell lines. (c) 2012 Elsevier Inc. All rights reserved.
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