Journal
STEROIDS
Volume 77, Issue 6, Pages 686-690Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2012.02.014
Keywords
Yucca desmettiana; Desmettianosides A and B; Furostanol saponins; Structure elucidation; Molluscicidal activity; Biomphalaria alexandrina
Funding
- Fayoum University
- PNG Gerolymatos
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Bioactivity-guided separation of the aqueous methanolic extract of Yucca desmettiana leaves, which in a preliminary screening exhibited significant molluscicidal activity, led to the isolation and structure elucidation of two new steroidal saponins (1 and 2). The structures of desmettianosides A and B, identified as bisdesmosidic furostanol glycosides with six and five sugar units, respectively, were established by detailed spectroscopic analyses of their NMR and MS data. Compounds 1 and 2 exhibited high molluscicidal activity against Biomphalaria alexandrina snails with LC100 values of 6 and 11 mg/L, respectively. (c) 2012 Published by Elsevier Inc.
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