Journal
STEROIDS
Volume 77, Issue 13, Pages 1438-1445Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2012.08.008
Keywords
Microwave; Steroidal quinolines; beta-Bromovinylaldehyde; Arylamine; Antimicrobial
Funding
- Department of Science & Technology, New Delhi
- CSIR, New Delhi
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The preparation of A-ring and D-ring fused steroidal quinolines is described from one-pot reaction of steroidal beta-bromovinylaldehydes and arylamines in solvent-free and catalyst-free condition under microwave irradiation. The antimicrobial activities of the compounds were tested by agar diffusion assay and broth macro dilution method. Compounds 7a, 7e and 7g-h showed promising in vitro activity when tested against fungal pathogen Aspergillus niger whereas compounds 7e-h and 7j showed promising activity when tested against fungal pathogen Candida albicans. Compounds 7c and 7f showed potent inhibition against the growth of Gram negative bacteria Pseudomonas aeruginosa and compounds 7e, 7g-h and 7j inhibited the growth of tested Gram positive bacteria Bacillus subtilis and Staphylococcus aureus. (C) 2012 Elsevier Inc. All rights reserved.
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