4.2 Article

The first synthesis of Krempene B

Journal

STEROIDS
Volume 77, Issue 13, Pages 1398-1402

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2012.08.006

Keywords

Krempene B; Rearrangement; Witting reaction; Synthesis

Funding

  1. National Natural Science Foundation of China [21062002]
  2. Guangxi University for Nationalities [2010QD018, 2010ZD010]

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The synthesis of Krempene B, which can be isolated from the marine soft coral Cladiella krempfi, is achieved in 23.9% overall yield from commercially available 3 beta-acetoxy-5-pregnen-20-one by 11 steps. Key transformations include the dienone phenol rearrangement of steroids and Wittig reaction. (C) 2012 Elsevier Inc. All rights reserved.

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