Journal
STEROIDS
Volume 77, Issue 14, Pages 1551-1559Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2012.09.007
Keywords
Cytotoxicity; Pregnenolone; Hydrazide-hydrazone; Pyrazole; Thiazole; Thiophene
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Pregnenolone (1) was used as a template to develop new anticancer compounds. Ring D modification of 1 through its reaction with cyanoacetylhydrazine (2) gave the hydrazide-hydrazone derivative 3. The latter compound underwent heterocyclization reactions to give the pyrazole, pyridine, thiazole and thiophene derivatives of pregnenolone. The cytotoxicity of the newly synthesized heterocyclic steroids against three human tumor cell lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were studied. Some of tested compounds were found to exhibit much higher inhibitory effects towards the three tumor cell lines than the reference drug, doxorubicin. (c) 2012 Elsevier Inc. All rights reserved.
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