Journal
STEROIDS
Volume 75, Issue 11, Pages 754-759Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2009.10.014
Keywords
Sex; Sexual dimorphism; Cerebral ischemia; Androgens; Stroke
Funding
- NINDS NIH HHS [P01 NS049210-05, NS049210, P01 NS049210] Funding Source: Medline
- NINR NIH HHS [NR003521, R01 NR003521, R01 NR003521-16] Funding Source: Medline
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Biologic sex and sex steroids are important factors in clinical and experimental stroke. This review evaluates key evidence that biological sex strongly alters mechanisms and outcomes from cerebral ischemia. The role of androgens in male stroke is understudied and important to pursue given that male sex is a well known risk factor for human stroke. To date, male sex steroids remain largely evaluated at the bench rather than the bedside. We review recent advances in our understanding of androgens in the context of ischemic cell death and neuroprotection. We also highlight some possible molecular mechanisms by which androgens impact ischemic outcomes. (C) 2009 Published by Elsevier Inc.
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