Journal
STEROIDS
Volume 74, Issue 7, Pages 573-576Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2008.12.001
Keywords
Progesterone receptor; Cell cycle; Cyclin D; p21; p27; Cyclin-dependent kinase 2
Funding
- NCI NIH HHS [R01 CA123763, T32 CA009138] Funding Source: Medline
- NIDDK NIH HHS [R01 DK053825] Funding Source: Medline
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Multiple laboratories have investigated progesterone receptor (PR) involvement in breast cancer cell cycle progression. There is now a growing body of evidence demonstrating complex interactions between PR and cell cycle regulatory proteins. Here we review the current literature linking PR to cell cycle control and discuss gaps in the current knowledge. A more complete understanding of the relationships between PR and cell cycle regulatory molecules may reveal additional avenues for prevention and treatment of steroid receptor positive breast cancers. (C) 2008 Elsevier Inc. All rights reserved.
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