Journal
STEROIDS
Volume 74, Issue 12, Pages 950-955Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2009.07.001
Keywords
Ypsilandra thibetica; Liliaceae; Spirostanol saponins; Ypsilandrosides C-G; Cytotoxicity; Antifungal activity
Funding
- West Light Foundation of the Chinese Academy of Sciences [2908025712W1]
- State Key Laboratory of Phytochemistry and Plant Resources in West China [540806321211]
- Germplasm Bank of Wild Species and CAS Innovation Program of Kunming Institute of Botany
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A further phytochemical investigation on the whole plants of Ypsilandra thibetica yielded one sapogenin and 12 spirostanol saponins. Five of these are new compounds, designated as ypsilandrosides C-G (2-6). Their structures were determined by detailed spectroscopic analysis, including extensive 1D and 2D NMR data, and by the result of a hydrolytic reaction. Compounds 2-5 were rare steroidal saponins that an apiofuranosyl unit was directly linked at C-3 of the aglycone. Selected spirostanol saponins (2-6, 9) were tested for their cytotoxic activities against K562, SPC-A-1, BGC-823, Eca-109, and AGS cell lines. Compounds 6 and 9 showed moderate inhibitory activity against all five cell lines. The antifungal properties of the new spirostanol saponins (2-6) against Candida albicans were also determined. (C) 2009 Elsevier Inc. All rights reserved.
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