Journal
STEROIDS
Volume 74, Issue 2, Pages 256-263Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2008.11.011
Keywords
Pregnane derivatives; NMDA receptor; Structure-activity relationship; Patch-clamp recording
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The synthesis of several novel 5 alpha- and 5 beta-20-oxo-pegnane derivatives substituted in the position 3 and 7 of the steroid skeleton is described. Activity of synthesized compounds was studied in voltage-clamped cultured rat hippocampal neurons. Substituted derivatives inhibited NMDA-elicited neuronal activity. The relationship between biological activity and structure is discussed. (C) 2008 Published by Elsevier Inc.
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