Journal
STEROIDS
Volume 74, Issue 12, Pages 989-995Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2009.07.009
Keywords
Steroidal oximes; Synthesis; Antiproliferative activity; Cytotoxicity
Funding
- National Natural Science Foundation of China [20562001]
- Natural Science Foundation of Guangxi Province [0832106]
- Foundation of Guangxi Education Bureau [200707M5172]
Ask authors/readers for more resources
Hydroximinosteroids isolated from marine sponges display a variety of biological functions including cytotoxicity and anti-virus. In this study, we synthesized a series of hydroximinosteroid derivatives with a different functional group on the ring A or B and various side chains at position 17, and analyzed the cytotoxicity of these compounds against sk-Hep-1, H-292, PC-3 and Hey-1B cancer cells. Our results revealed that although a cholesterol-type side chain at position 17 is required for the biological activity of the compounds as we previously confirmed, elimination of the 4,5-double bond augmented the cytotoxic activity for the steroidal oximes. In addition, the presence of a hydroxy on 3- or 6-position of the steroidal nucleus resulted in a remarkable increase of cytotoxic activity. Our findings present more evidence showing the relationship between the chemical structure and biological function. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available