Journal
STEROIDS
Volume 73, Issue 5, Pages 568-573Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2008.01.009
Keywords
sponge; Ircinia aruensis; structure identification
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Chromatographic separation of the ethanolic extract of the marine sponge, Ircinia aruensis, resulted in the isolation and characterization of six new sterols. 5 alpha,6 alpha-Epoxy-26,27-dinorergosta-7,22-en-3 beta-ol (1), 5 alpha,6 alpha-epoxycholesta-7,22-en-3 beta-ol (2), 5 alpha,6 alpha-epoxyergosta-7,24(28)-en-3 beta-ol (3), 5 alpha,6 alpha-epoxyergosta-7-en-3 beta-ol (4), 5 alpha,6 alpha-epoxystigmasta-7,22-en-3 beta-ol (5), 5 alpha,6 alpha-epoxystigmasta-7-en-3 beta-ol (6). The structures of the new compounds were determined on the basis of extensive spectroscopic data (IR, MS, H-1 and C-13 NMR, HMQC, and HMBC) analyses. The cytotoxic of 1-3 toward a limited panel of cancer cell lines is also reported. (C) 2008 Elsevier Inc. All rights reserved.
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