Journal
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
Volume 92, Issue 6, Pages 388-392Publisher
KARGER
DOI: 10.1159/000365226
Keywords
Paroxysmal nonkinesigenic dyskinesia; Paroxysmal dyskinesia; Deep brain stimulation; Globus pallidus internus
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Funding
- Medtronic Inc.
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Paroxysmal nonkinesigenic dyskinesia (PNKD) causes episodes of treatment-resistant involuntary movements. Previous case reports showed effective treatment of PNKD with deep brain stimulation (DBS). We report 2 patients in whom DBS was highly successful when other treatment modalities had failed. Methods: Two patients aged 34 and 24 years with a longstanding history of PNKD were treated with globus pallidus internus (GPi) DBS. Motor effects were monitored and followed up postoperatively and again at 6 months after surgery. Results: Both patients responded very well to GPi DBS with complete suppression of dyskinesia after surgery in 1 patient and in the second after an additional adjustment of stimulation. Conclusion: GPi DBS might be an effective alternative treatment modality for PNKD. (C) 2014 S. Karger AG, Basel
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